Cerebral blood flow and BOLD fMRI responses to hypoxia in awake and anesthetized rats

@article{Duong2007CerebralBF,
  title={Cerebral blood flow and BOLD fMRI responses to hypoxia in awake and anesthetized rats},
  author={Timothy Q. Duong},
  journal={Brain Research},
  year={2007},
  volume={1135},
  pages={186-194}
}
This study investigated the functional MRI responses to graded hypoxia in awake/restrained and anesthetized animals by measuring cerebral blood flow (CBF) and blood oxygenation (BOLD) changes and estimating changes in cerebral metabolic rate of oxygen (CMRO2). Hypoxia in isoflurane anesthetized rats reduced blood pressure but did not change heart rate and respiration rate. In contrast, hypoxia in awake animals showed compensatory responses by sustaining blood pressure, increasing heart rate and… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 36 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 33 REFERENCES

Evidence of the limitations of water as a freely diffusible tracer in brain of the Rhesus monkey

  • J. O. Eichling, M. E. Raichle, L. R., M. M. Ter-Pogossian
  • Circ . Res .
  • 1974
Highly Influential
1 Excerpt

Similar Papers

Loading similar papers…