Cerebral atrophy, apolipoprotein E varepsilon4, and rate of decline in everyday function among patients with amnestic mild cognitive impairment.

@article{Okonkwo2010CerebralAA,
  title={Cerebral atrophy, apolipoprotein E varepsilon4, and rate of decline in everyday function among patients with amnestic mild cognitive impairment.},
  author={Ozioma C. Okonkwo and Michael L. Alosco and Beth A. Jerskey and Lawrence H. Sweet and Brian R. Ott and Geoffrey Tremont},
  journal={Alzheimer's & dementia : the journal of the Alzheimer's Association},
  year={2010},
  volume={6 5},
  pages={404-11}
}
BACKGROUND Patients with amnestic mild cognitive impairment (MCI) demonstrate decline in everyday function. In this study, we investigated whether whole brain atrophy and apolipoprotein E (APOE) genotype are associated with the rate of functional decline in MCI. METHODS Participants were 164 healthy controls, 258 MCI patients, and 103 patients with mild Alzheimer's disease (AD), enrolled in the Alzheimer's Disease Neuroimaging Initiative. They underwent brain MRI scans, APOE genotyping, and… CONTINUE READING
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