Cerebral anaerobic glycolysis and reduced cerebral oxygen transport in human cerebral malaria.

@article{Warrell1988CerebralAG,
  title={Cerebral anaerobic glycolysis and reduced cerebral oxygen transport in human cerebral malaria.},
  author={David A. Warrell and Nicholas J White and N. Veall and Sornchai Looareesuwan and Pornthep Chanthavanich and Rodney E. Phillips and Juntra Karbwang and Praneet Pongpaew and Sanjeev Krishna},
  journal={Lancet},
  year={1988},
  volume={2 8610},
  pages={534-8}
}
In 12 patients comatose with cerebral malaria, cerebral blood flow was 52.2 (SE 4.0) ml/100 g per min, within the reported range for healthy controls, but cerebral vascular resistance was raised at 1.66 (0.19) mm Hg/ml per 100 g per min. Cerebral oxygen consumption (1.90 [0.23] ml/100 g per min), and cerebral arteriovenous oxygen content difference (3.5 [0.43] ml/dl) were subnormal, while cerebral venous pO2 (5.7 [0.2] kpA) was raised. After recovery of consciousness there were significant… CONTINUE READING
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