Cerebral amyloid angiopathy: major contributor or decorative response to Alzheimer's disease pathogenesis.

@article{Castellani2004CerebralAA,
  title={Cerebral amyloid angiopathy: major contributor or decorative response to Alzheimer's disease pathogenesis.},
  author={Rudy J. Castellani and Mark A. Smith and George Perry and Robert P Friedland},
  journal={Neurobiology of aging},
  year={2004},
  volume={25 5},
  pages={599-602; discussion 603-4}
}
Amyloid deposition within cerebral vessels, or cerebral amyloid angiopathy (CAA), is common in advanced age and even more common in Alzheimer's disease. CAA may be complicated by lobar intracerebral hemorrhage, while rare kindreds of autosomal dominant CAA also show propensity for intracerebral hemorrhage, due to germline mutations in specific amyloidogenic precursor proteins and apparent compromise of structural integrity of the blood vessel wall due to marked amyloid deposition. The… CONTINUE READING

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