Cerebral amino acid, norepinephrine and nitric oxide metabolism in CNS oxygen toxicity.

@article{Zhang1993CerebralAA,
  title={Cerebral amino acid, norepinephrine and nitric oxide metabolism in CNS oxygen toxicity.},
  author={Junan Zhang and Yun Su and Tim D Oury and Claude A. Piantadosi},
  journal={Brain research},
  year={1993},
  volume={606 1},
  pages={56-62}
}
CNS oxygen (O2) toxicity is complex, and the etiology of its most severe manifestation, O2 convulsions, is yet to be determined. A role for depletion of the brain GABA pool has been proposed, although recent data have implicated production of reactive O2 species, e.g. H2O2, in this process. We hypothesized that the production of H2O2 and NH3 produced by monoamine oxidase (MAO) would lead to depletion of GABA and production of nitric oxide (NO.) respectively, and thereby enhance CNS O2 toxicity… CONTINUE READING
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