Cerebral Synthesis and Release of Kynurenic Acid: Antagonist of Excitatory Amino Acid Receptors An Endogenous

@inproceedings{Swartz1990CerebralSA,
  title={Cerebral Synthesis and Release of Kynurenic Acid: Antagonist of Excitatory Amino Acid Receptors An Endogenous},
  author={Kenton Jon Swartz and Matthew John During and Andrew Freese and M. Flint Beal},
  year={1990}
}
Excitatory amino acid (EAA)-mediated synaptic transmission is the most prevalent excitatory system within the mammalian brain. Activation of EAA receptors has been postulated to contribute to neuronal cell death in stroke, epilepsy, hypoglycemia, and Huntington’s disease. Kynurenic acid is an endogenous substance that inhibits EAA receptors and may therefore influence important physiologic and pathologic processes. The release of intracerebrally synthesized kynurenic acid into the extracellular… CONTINUE READING

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