Cerebral Ischemic Reperfusion Injuries (CIRI)

@inproceedings{Jiang2018CerebralIR,
  title={Cerebral Ischemic Reperfusion Injuries (CIRI)},
  author={Weijian Jiang and Ann M. Dvorak and Yan Miao Qu and Zhongsong Shi and Benyan Luo and John H Zhang},
  booktitle={Springer Series in Translational Stroke Research},
  year={2018}
}
Stroke is one of the leading causes of death, and acute ischemic stroke (AIS) is the most common form. Tissue plasminogen activator (tPA) is the only FDA-approved drug for recanalization in AIS with narrow therapeutic window. In this chapter, we will discuss the activation of gelatinases (MMP-2/9), one of the major mediators in cerebral ischemia and reperfusion injury (CIRI) with exogenous tPA in AIS. First, we briefly overview the structure of microvascular beds and the homeostasis of… CONTINUE READING

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