Cerebral Ischemia Enhances Polyamine Oxidation: Identification of Enzymatically Formed 3-Aminopropanal as an Endogenous Mediator of Neuronal and Glial Cell Death

@article{Ivanova1998CerebralIE,
  title={Cerebral Ischemia Enhances Polyamine Oxidation:  Identification of Enzymatically Formed 3-Aminopropanal as  an Endogenous Mediator of Neuronal and Glial Cell Death },
  author={Svetlana M. Ivanova and Galina Botchkina and Yousef Al-Abed and Malcolm Meistrell and Franak M Batliwalla and Janet M. Dubinsky and Constantino Iadecola and Haichao Wang and Peter K. Gregersen and John W. Eaton and Kevin J Tracey},
  journal={The Journal of Experimental Medicine},
  year={1998},
  volume={188},
  pages={327 - 340}
}
To elucidate endogenous mechanisms underlying cerebral damage during ischemia, brain polyamine oxidase activity was measured in rats subjected to permanent occlusion of the middle cerebral artery. Brain polyamine oxidase activity was increased significantly within 2 h after the onset of ischemia in brain homogenates (15.8 +/- 0.9 nmol/h/mg protein) as compared with homogenates prepared from the normally perfused contralateral side (7.4 +/- 0.5 nmol/h/mg protein) (P <0.05). The major catabolic… CONTINUE READING