Cereblon and its downstream substrates as molecular targets of immunomodulatory drugs.

Abstract

Thalidomide was first developed as a sedative around 60 years ago, but exhibited teratogenicity, leading to serious defects such as limb deformities. Nevertheless, thalidomide is now recognized as a therapeutic drug for the treatment of Hansen's disease and myeloma. Immunomodulatory drugs (IMiDs), a new class of anti-cancer drug derived from thalidomide… (More)
DOI: 10.1007/s12185-016-2073-4

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