Cerebellar stimulation reduces inducible nitric oxide synthase expression and protects brain from ischemia.

@article{Galea1998CerebellarSR,
  title={Cerebellar stimulation reduces inducible nitric oxide synthase expression and protects brain from ischemia.},
  author={Elena Galea and Eugene V Golanov and Douglas L Feinstein and Keith A Kobylarz and Sara B Glickstein and Donald J. Reis},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={1998},
  volume={274 6},
  pages={H2035-H2045}
}
A focal infarction produced by occlusion of the middle cerebral artery (MCAO) in spontaneously hypertensive rats induced expression of inducible nitric oxide synthase (iNOS) mRNA, measured by competitive reverse transcription-polymerase chain reaction. The mRNA appeared simultaneously in the ischemic core and penumbra at 8 h, peaked between 14 and 24 h, and disappeared by 48 h. At 24 h, inducible nitric oxide synthase (iNOS)-like immunoreactivity was present in the endothelium of cerebral… CONTINUE READING

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