Cerebellar hypoplasia in the Gunn rat is associated with quantitative changes in neurotypic and gliotypic proteins.


We are characterizing toxicant-induced injury to the nervous system by measuring nervous system, cell-type specific proteins together with accompanying changes in morphology and behavior. In the present study, cerebellar neurotoxicity was assessed in the Gunn rat, an autosomal recessive mutant that exhibits degeneration of Purkinje cells due to hereditary… (More)


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