Cerebellar gene expression profiling and eQTL analysis in inbred mouse strains selected for ethanol sensitivity.

@article{Maclaren2005CerebellarGE,
  title={Cerebellar gene expression profiling and eQTL analysis in inbred mouse strains selected for ethanol sensitivity.},
  author={Erik J Maclaren and James M. Sikela},
  journal={Alcoholism, clinical and experimental research},
  year={2005},
  volume={29 9},
  pages={1568-79}
}
BACKGROUND Inbred Long-Sleep (ILS) and Inbred Short-Sleep (ISS) mice exhibit striking differences in a number of alcohol and drug related behaviors. This study examined the expression levels of more than 39,000 transcripts in these strains in the cerebellum, a major target of ethanol's actions in the CNS, to find differentially expressed (DE) candidate genes for these phenotypes. METHODS Genes that were differentially expressed between the strains were identified using oligonucleotide arrays… CONTINUE READING
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