Cerebellar gamma-aminobutyric acid type A receptors: pharmacological subtypes revealed by mutant mouse lines.

@article{Mkel1997CerebellarGA,
  title={Cerebellar gamma-aminobutyric acid type A receptors: pharmacological subtypes revealed by mutant mouse lines.},
  author={Riikka M{\"a}kel{\"a} and Mikko Uusi-Oukari and Gregg E Homanics and Joseph J. Quinlan and Leonard L. Firestone and William Wisden and Esa R Korpi},
  journal={Molecular pharmacology},
  year={1997},
  volume={52 3},
  pages={380-8}
}
The vast molecular heterogeneity of brain gamma-aminobutyric acid type A (GABAA) receptors forms the basis for receptor subtyping. Using autoradiographic techniques, we established the characteristics of cerebellar granule cell GABAA receptors by comparing wild-type mice with those with a targeted disruption of the alpha6 subunit gene. Cerebellar granule cells of alpha6(-/-) animals have severe deficits in high affinity [3H]muscimol and [3H]SR 95531 binding to GABA sites, in agonist-insensitive… CONTINUE READING

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