Cerebellar aminergic neuromodulation: towards a functional understanding

@article{Schweighofer2004CerebellarAN,
  title={Cerebellar aminergic neuromodulation: towards a functional understanding},
  author={Nicolas Schweighofer and Kenji Doya and Shinya Kuroda},
  journal={Brain Research Reviews},
  year={2004},
  volume={44},
  pages={103-116}
}
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References

SHOWING 1-10 OF 140 REFERENCES

Motor learning deficits in aged rats are correlated with loss of cerebellar noradrenergic function

Serotonin-Driven Long-Range Inhibitory Connections in the Cerebellar Cortex

TLDR
Serotonin modulation of Lugaro cells may constitute an intracortical switch involved in information patterning at the level of Golgi cells and granule cells populations, and particularly in synchronizations recorded along the transverse axisin vivo.

Diffusion of nitric oxide can facilitate cerebellar learning: A simulation study.

TLDR
It is shown that biologically plausible diffusion leads to an increase in information transfer of the error signals to the PCs when the IO firing rate is ultra-low, which enhances cerebellar learning as shown by improved performance in an arm-reaching task.

Serotonergic control of cerebellar mossy fiber activity by modulation of signal transfer by rat pontine nuclei neurons.

TLDR
5-HT increases the excitability of PN neurons but decreases the synaptic transmission on them, and the selective enhancement of synaptic facilitation may, however, allow high-frequency inputs to effectively drive Pn neurons, thus the PN may act as a high-pass filter during periods of 5-HT release.

A Theory of Cerebellar Function

Metalearning and neuromodulation

  • K. Doya
  • Psychology, Biology
    Neural Networks
  • 2002

The Cerebellar Serotoninergic System and its Possible Involvement in Cerebellar Ataxia

  • P. Trouillas
  • Biology, Psychology
    Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
  • 1993
TLDR
In rat, cat and oppossum, the perikarya of origin are located in the brain stem raphe nuclei and in other brainstem structures, the projections to the cerebellar layers and deep nuclei include synaptic connections, but also non synaptic terminals, espedaily in a diffuse cortical plexus.

Monoaminergic long-term facilitation of GABA-mediated inhibitory transmission at cerebellar synapses

A model of cerebellar metaplasticity.

TLDR
This work proposes here that the cerebellar cortex may use metaplasticity, and demonstrates this by introducing the Cerebellar Adaptive Rate Learning (CARL) algorithm that concentrates learning on those Purkinje cell synapses whose adaptation is most relevant to learning an overall pattern.

Cellular mechanisms of cerebellar LTD

...