Cerebellar adrenomedullin: A new target for blood pressure regulation

  title={Cerebellar adrenomedullin: A new target for blood pressure regulation},
  author={Leticia Figueira and Anita Israel},
  journal={Therapeutic Targets for Neurological Diseases},
Adrenomedullin (AM) and their receptor components, CRLR, RAMP1, RAMP2 and RAMP3 are widely expressed in the central nervous system, including cerebellum. Recent evidence suggests a role for cerebellar adrenomedullinergic system in blood pressure (BP) regulation. We assessed AM, RAMP1, RAMP2, RAMP3 and CRLR expression; and AM receptor signaling pathway in the cerebellar vermis of WKY and SHR rats.  Our findings demonstrated that CRLR, RAMP1 and RAMP3  expression was higher in cerebellum of SHR… Expand

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