Cerebellar Long-term Depression is Deficient in Niemann–Pick Type C Disease Mice

@article{Sun2010CerebellarLD,
  title={Cerebellar Long-term Depression is Deficient in Niemann–Pick Type C Disease Mice},
  author={Cheng-long Sun and Li-da Su and Qiong Li and Xin-Xin Wang and Ying Shen},
  journal={The Cerebellum},
  year={2010},
  volume={10},
  pages={88-95}
}
Niemann–Pick type C disease (NPC) is an autosomal recessive lipidosis characterized by progressive neurodegeneration. Although several studies have revealed unusual accumulation of unesterfied cholesterol in astrocytic lysosome of NPC, pathophysiological basis of cerebellar neuronal dysfunction remains unclear. We compared parallel fiber-Purkinje cell synaptic transmission and long-term depression (LTD) in +/+npc nih (npc +/+) and −/−npc nih (npc −/−) mice. Our data showed that adenosine A1… CONTINUE READING