Cerebellar Adrenomedullinergic System. Role in Cardiovascular Regulation.

  title={Cerebellar Adrenomedullinergic System. Role in Cardiovascular Regulation.},
  author={Leticia Figueira and A. Israel},
  journal={Advances in experimental medicine and biology},
Adrenomedullin (AM) is a multifunctional peptide which exerts numerous biological activities through the activation of AM1 (CRLR + RAMP2) and AM2 (CRLR + RAMP3) receptors. AM immunoreactivity, AM binding sites and CRLR, RAMP1, RAMP2 and RAMP3 are expressed in rat cerebellar vermis. AM binding sites are discretely and differentially distributed in the rat cerebellar cortex with higher levels detected in SHR when compared with WKY rats. In addition, there is an up-regulation of cerebellar CGRP1… Expand
Dysregulation of Cerebellar Adrenomedullin Signaling During Hypertension
In the cerebellar vermis of normotensive rats, AM increases cGMP, NO, cAMP production, and ERK1/2 phosphorylation, while decreases basal antioxidant enzyme activity, which supports a dysregulation of several AM signaling pathways during hypertension in cerebellary vermis. Expand
Twirling reinforcing-reducing manipulation-central mechanism underlying antihypertensive effect on spontaneous hypertension in rats.
TRRM could significantly lower the BP of SHRs by improving the cerebral glucose metabolism of the activated key brain regions and the underlying central mechanism may be related to the central rennin-angiotensin system and neurotransmission. Expand


Role of cerebellar adrenomedullin in blood pressure regulation
It is shown that AM binding sites are altered in cerebellum during hypertension, suggesting a role for cerebellar adrenomedullinergic system in blood pressure regulation and a novel mechanism of BP control which has not been described so far. Expand
Effect of Valsartan on Cerebellar Adrenomedullin System Dysregulation During Hypertension
It is demonstrated that valsartan is able to reverse the dysregulation of cerebellar adrenomedullinergic system; and they suggest that altered AM system in the cerebellum could represent the primary abnormality leading to hypertension. Expand
Autonomic and neuroendocrine actions of adrenomedullin in the brain: mechanisms for homeostasis
It is shown that circulating ADM activates neurons, including nitric oxide-producing neurons, in autonomic centers of the brain such as the hypothalamic paraventricular nucleus (PVN), and that ADM is an important transmitter of brain autonomic pathways which are involved in regulating homeostatic balance. Expand
A possible mechanism for the action of adrenomedullin in brain to stimulate stress hormone secretion.
It is proposed that AM produced in the brain may be an important neuromodulator of the hormonal stress response. Expand
Adrenomedullin receptors: pharmacological features and possible pathophysiological roles
Three receptor activity modifying proteins (RAMPs) chaperone calcitonin-like receptor (CLR) to the cell surface. RAMP2 enables CLR to form an adrenomedullin (AM)-specific receptor that is sensitiveExpand
The pharmacology of Adrenomedullin 2/Intermedin
In tissues and in animals it is frequently antagonised by CGRP and AM antagonists; however, situations exist in which an AM2 response is maintained even in the presence of supramaximal concentrations of these antagonists. Expand
Receptor activity-modifying proteins: RAMPing up adrenomedullin signaling.
Certain conditions, such as pregnancy, cardiovascular disease, and sepsis, are associated with robust and dynamic changes in the expression of AM and AM receptor proteins, which together represent an elegant mechanism for altering the physiological responsiveness or function of AM. Expand
A review of the biological properties and clinical implications of adrenomedullin and proadrenomedullin N-terminal 20 peptide (PAMP), hypotensive and vasodilating peptides
Human AM gene delivery improves hypertension, renal function, cardiac hypertrophy and nephrosclerosis in the hypertensive rats, and recently established AM knockout mice lines revealed that AM is essential for development of vitelline vessels of embryo. Expand
Adrenomedullin and the control of fluid and electrolyte homeostasis.
  • W. K. Samson
  • Biology, Medicine
  • Annual review of physiology
  • 1999
The biologic actions of the proadrenomedullin-derived peptides seem well coordinated to contribute to the physiologic regulation of volume and electrolyte homeostasis. Expand
Role of nitric oxide-cGMP pathway in adrenomedullin-induced vasodilation in the rat.
Results suggest that the cGMP-specific phosphodiesterase inhibitor E-4021 is involved in the mechanism of AM-induced vasorelaxation, at least in the rat aorta and kidney. Expand