Cercariform cells: Another cytologic feature distinguishing solid pseudopapillary neoplasms from pancreatic endocrine neoplasms and acinar cell carcinomas in endoscopic ultrasound‐guided fine‐needle aspirates

@article{Samad2013CercariformCA,
  title={Cercariform cells: Another cytologic feature distinguishing solid pseudopapillary neoplasms from pancreatic endocrine neoplasms and acinar cell carcinomas in endoscopic ultrasound‐guided fine‐needle aspirates},
  author={Arbaz Samad and Akeesha A. Shah and Edward B Stelow and Mariam Alsharif and Stuart E H Cameron and Stefan E. Pambuccian},
  journal={Cancer Cytopathology},
  year={2013},
  volume={121}
}
Solid pseudopapillary neoplasm (SPPN) is a rare tumor of unknown origin that occurs predominantly in the body or tail of the pancreas in young women. The authors recently identified cercariform (Greek: tailed) cells, similar to those described in urothelial carcinomas, as a consistent cytologic feature in ultrasound‐guided fine‐needle aspiration (EUS‐FNA) samples from SPPNs. The objective of the current multi‐institutional study was to define the value of these cells in the differential… 
Utility of cytomorphology in distinguishing solid pseudopapillary neoplasm of pancreas from pancreatic neuroendocrine tumor with emphasis on nuclear folds and nuclear grooves
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This work aims to differentiate SPN from Pan‐NET based on cyto‐morphology; to classify nuclear membrane (NM) irregularities or nuclear folds into four grades and see whether they bear any difference with respect to the two entities.
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216 SOLID-PSEUDOPAPILLARY NEOPLASM OF THE PANCREAS – COMPARISONS BETWEEN MAGNETIC RESONANCE AND HISTOLOGICAL FINDINGS
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This review gives a comprehensive update on the pathologic, clinical, and molecular features of SPNs, particularly addressing issues and challenges related to diagnosis.
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Cercariform cells are slender cells with a bulbous end and a unipolar long cytoplasmic process, resembling Schistosoma cercariae, most commonly encountered in urothelial carcinoma, but they can also be seen in other neoplasms, raising the possibility that this cytomorphological feature can be exploited to aid in diagnosis.
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Solid pseudopapillary neoplasm of the pancreas is a rare entity with low malignant potential and excellent overall prognosis, and definite treatment is surgical resection.
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It is crucial to diagnose this rare tumor cytologically from other pancreatic tumors by its characteristic cytological features and plan appropriately for the surgical management to improve patient care.
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Pancreatic solid-pseudopapillary neoplasm can be confidently diagnosed on limited cytological material, with limited panel immunohistochemistry aiding diagnosis in atypical cases, according to a well-characterized cohort of 22 patients.
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