Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy.

@article{Zheng2006CeramidesAO,
  title={Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy.},
  author={Wenjing Zheng and Jessica Kollmeyer and Holly Symolon and Amin A. Momin and Elizabeth Munter and Elaine Ying Wang and Samuel Aidan Kelly and Jeremy C. Allegood and Ying Liu and Qiong Peng and Harsha Ramaraju and M. Cameron Sullards and Myles C. Cabot and Alfred H. Merrill},
  journal={Biochimica et biophysica acta},
  year={2006},
  volume={1758 12},
  pages={1864-84}
}
Sphingolipids are comprised of a backbone sphingoid base that may be phosphorylated, acylated, glycosylated, bridged to various headgroups through phosphodiester linkages, or otherwise modified. Organisms usually contain large numbers of sphingolipid subspecies and knowledge about the types and amounts is imperative because they influence membrane structure, interactions with the extracellular matrix and neighboring cells, vesicular traffic and the formation of specialized structures such as… CONTINUE READING
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