Ceramides - Lipotoxic Inducers of Metabolic Disorders.


In obesity and dyslipidemia, the oversupply of fat to tissues not suited for lipid storage induces cellular dysfunction that underlies diabetes and cardiovascular disease (i.e., lipotoxicity). Of the myriad lipids that accrue under these conditions, sphingolipids such as ceramide or its metabolites are amongst the most deleterious because they disrupt… (More)
DOI: 10.1016/j.tem.2015.07.006


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