Ceramide signaling in mammalian epidermis.

@article{Uchida2014CeramideSI,
  title={Ceramide signaling in mammalian epidermis.},
  author={Yoshikazu Uchida},
  journal={Biochimica et biophysica acta},
  year={2014},
  volume={1841 3},
  pages={
          453-62
        }
}
Ceramide, the backbone structure of all sphingolipids, as well as a minor component of cellular membranes, has a unique role in the skin, by forming the epidermal permeability barrier at the extracellular domains of the outermost layer of the skin, the stratum corneum, which is required for terrestrial mammalian survival. In contrast to the role of ceramide in forming the permeability barrier, the signaling roles of ceramide and its metabolites have not yet been recognized. Ceramide and/or its… CONTINUE READING

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