Ceramide potentiates, but sphingomyelin inhibits, vitamin D-induced keratinocyte differentiation: comparison between keratinocytes and HL-60 cells

@article{Pillai1999CeramidePB,
  title={Ceramide potentiates, but sphingomyelin inhibits, vitamin D-induced keratinocyte differentiation: comparison between keratinocytes and HL-60 cells},
  author={S. Pillai and M. Mahajan and M. Carlomusto},
  journal={Archives of Dermatological Research},
  year={1999},
  volume={291},
  pages={284-289}
}
  • S. Pillai, M. Mahajan, M. Carlomusto
  • Published 1999
  • Biology, Medicine
  • Archives of Dermatological Research
  • Abstract Differentiation of epidermal keratinocytes and leukemia HL-60 cells induced by 1,25-dihydroxyvitamin D [1,25(OH) 2 D] has been reported to be mediated, at least in part, by increases in cellular ceramide levels. Ceramides produced by 1,25(OH) 2 D-induced sphingomyelin (SM) hydrolysis also contribute to the permeability barrier lipids in keratinocytes. Exogenously supplied SM is taken up by mammalian cells, including keratinocytes, and is incorporated into cellular pools. However, the… CONTINUE READING
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