Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis.

@article{Lamour2007CeramideKU,
  title={Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis.},
  author={Nadia F. Lamour and Robert V. Stahelin and Dayanjan Shanaka Wijesinghe and Michael W. Maceyka and Elaine Ying Wang and Subramaniam Ramachandran and Alfred H. Merrill and Wonhwa Cho and Charles E Chalfant},
  journal={Journal of lipid research},
  year={2007},
  volume={48 6},
  pages={
          1293-304
        }
}
Ceramide kinase (CERK) is a critical mediator of eicosanoid synthesis, and its product, ceramide-1-phosphate (C1P), is required for the production of prostaglandins in response to several inflammatory agonists. In this study, mass spectrometry analysis disclosed that the main forms of C1P in cells were C(16:0) C1P and C(18:0) C1P, suggesting that CERK uses ceramide transported to the trans-Golgi apparatus by ceramide transport protein (CERT). To this end, downregulation of CERT by RNA… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 38 CITATIONS

Ceramide function in the brain: when a slight tilt is enough

  • Cellular and Molecular Life Sciences
  • 2012
VIEW 18 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Role of Ceramide Kinase in Breast Cancer Progression

VIEW 14 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Visualizing sphingolipid biosynthesis in cells.

  • Chemistry and physics of lipids
  • 2019
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 42 REFERENCES

Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2.

  • The Journal of biological chemistry
  • 2004
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Similar Papers