Ceramide inhibits phospholipase D in a cell-free system.

  title={Ceramide inhibits phospholipase D in a cell-free system.},
  author={Mark E. Venable and Alicia Bielawska and Lina M Obeid},
  journal={The Journal of biological chemistry},
  volume={271 40},
Recent evidence in whole cells has implicated ceramide in the regulation of phospholipase D (PLD). In intact HL-60 cells, phorbol myristate acetate (PMA) activated PLD as measured by [3H]palmitate-labeled phosphatidylcholine conversion to phosphatidylethanol in the presence of 2% ethanol. C6-Ceramide completely inhibited PLD activation after 4 h of treatment and was maximally active at 10 microM. The activity was structurally specific in that the structural analogs 4,5-dihydro-C6-ceramide and… CONTINUE READING


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