Ceramide inhibits axonal growth and nerve growth factor uptake without compromising the viability of sympathetic neurons.

@article{Chaves2001CeramideIA,
  title={Ceramide inhibits axonal growth and nerve growth factor uptake without compromising the viability of sympathetic neurons.},
  author={E P de Chaves and Marianne Bussi{\`e}re and B J MacInnis and Dennis E. Vance and Robert B. Campenot and Jean E. Vance},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 39},
  pages={
          36207-14
        }
}
  • E P de Chaves, Marianne Bussière, +3 authors Jean E. Vance
  • Published in
    The Journal of biological…
    2001
  • Biology, Medicine
  • Ceramide inhibits axonal growth of cultured rat sympathetic neurons when the ceramide content of distal axons, but not cell bodies, is increased (Posse de Chaves, E. I., Bussiere, M. Vance, D. E., Campenot, R. B., and Vance, J.E. (1997) J. Biol. Chem. 272, 3028-3035). We now report that inhibition of growth does not result from cell death since although ceramide is a known apoptotic agent, C(6)-ceramide given to the neurons for 24 h did not cause cell death but instead protected the neurons… CONTINUE READING

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