Ceramide-induced translocation of protein kinase C-delta and -epsilon to the cytosol. Implications in apoptosis.

@article{Sawai1997CeramideinducedTO,
  title={Ceramide-induced translocation of protein kinase C-delta and -epsilon to the cytosol. Implications in apoptosis.},
  author={Hirofumi Sawai and Tatsuma Okazaki and Yoshifumi Takeda and Masaro Tashima and Hiroyoshi Sawada and Minoru Okuma and Shuji Kishi and Hisanori Umehara and Naochika Domae},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 4},
  pages={2452-8}
}
Ceramide is now recognized as an intracellular lipid signal mediator, which induces various kinds of cell functions including apoptosis. Ceramide-induced apoptosis was reported to be blocked by 12-O-tetradecanoylphorbol 13-acetate, a protein kinase C (PKC) activator, but its mechanism remained unclear. Therefore, we investigated whether ceramide has any effects on PKC in the induction of apoptosis. We here report that N-acetylsphingosine (synthetic membrane-permeable ceramide) induced… CONTINUE READING