Ceramide-induced intracellular oxidant formation, iron signaling, and apoptosis in endothelial cells: protective role of endogenous nitric oxide.

@article{Matsunaga2004CeramideinducedIO,
  title={Ceramide-induced intracellular oxidant formation, iron signaling, and apoptosis in endothelial cells: protective role of endogenous nitric oxide.},
  author={Toshiyuki Matsunaga and Srigiridhar Kotamraju and Shasi V Kalivendi and Anuradha Dhanasekaran and Joy Joseph and Balaraman Kalyanaraman},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 27},
  pages={28614-24}
}
Sphingolipid ceramide (N-acetylsphingosine), a bioactive second messenger lipid, was shown to activate reactive oxygen species (ROS), mitochondrial oxidative damage, and apoptosis in neuronal and vascular cells. The proapoptotic effects of tumor necrosis factor-alpha, hypoxia, and chemotherapeutic drugs were attributed to increased ceramide formation. Here we investigated the protective role of nitric oxide (.NO) during hydrogen peroxide (H(2)O(2))-mediated transferrin receptor (TfR)-dependent… CONTINUE READING
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