Ceramide-induced inhibition of T lymphocyte voltage-gated potassium channel is mediated by tyrosine kinases.

@article{Gulbins1997CeramideinducedIO,
  title={Ceramide-induced inhibition of T lymphocyte voltage-gated potassium channel is mediated by tyrosine kinases.},
  author={Erich Gulbins and Ildik{\'o} Kurit{\'a}rn{\'e} Szab{\'o} and K Baltzer and Florian Lang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 14},
  pages={7661-6}
}
The n-type K+ channel (n-K+, Kv1.3) in lymphocytes has been recently implicated in the regulation of Fas-induced programmed cell death. Here, we demonstrate that ceramide, a lipid metabolite synthesized upon Fas receptor ligation, inhibits n-K+ channel activity and induces a tyrosine phosphorylation of the Kv1.3 protein in Jurkat T lymphocytes. Tyrosine phosphorylation of the n-K+ channel correlated with an activation of the Src-like tyrosine kinase p56lck upon cellular treatment with the… CONTINUE READING

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