Ceramide glycosylation catalyzed by glucosylceramide synthase and cancer drug resistance.

@article{Liu2013CeramideGC,
  title={Ceramide glycosylation catalyzed by glucosylceramide synthase and cancer drug resistance.},
  author={Yong-Yu Liu and Ronald A. Hill and Yu-Teh Li},
  journal={Advances in cancer research},
  year={2013},
  volume={117},
  pages={59-89}
}
Glucosylceramide synthase (GCS), converting ceramide to glucosylceramide, catalyzes the first reaction of ceramide glycosylation in sphingolipid metabolism. This glycosylation by GCS is a critical step regulating the modulation of cellular activities by controlling ceramide and glycosphingolipids (GSLs). An increase of ceramide in response to stresses, such… CONTINUE READING

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