Ceramide generation in situ alters leukocyte cytoskeletal organization and beta 2-integrin function and causes complete degranulation.

@article{Feldhaus2002CeramideGI,
  title={Ceramide generation in situ alters leukocyte cytoskeletal organization and beta 2-integrin function and causes complete degranulation.},
  author={Michael J. Feldhaus and Andrew S. Weyrich and Guy A. Zimmerman and Thomas M McIntyre},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 6},
  pages={4285-93}
}
Ceramide levels increase in activated polymorphonuclear neutrophils, and here we show that endogenous ceramide induced degranulation and superoxide generation and increased surface beta(2)-integrin expression. Ceramide accumulation reveals a bifurcation in integrin function, as it abolished agonist-induced adhesion to planar surfaces, yet had little effect on homotypic aggregation. We increased cellular ceramide content by treating polymorphonuclear neutrophils with sphingomyelinase C and… CONTINUE READING
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