Ceramide-domain formation and collapse in lipid rafts: membrane reorganization by an apoptotic lipid.

@article{Silva2007CeramidedomainFA,
  title={Ceramide-domain formation and collapse in lipid rafts: membrane reorganization by an apoptotic lipid.},
  author={Liana C. Silva and Rodrigo F. M. de Almeida and Bruno M Castro and Alexander E Fedorov and Manuel Prieto},
  journal={Biophysical journal},
  year={2007},
  volume={92 2},
  pages={502-16}
}
The effect of physiologically relevant ceramide concentrations (< or = 4 mol %) in raft model membranes with a lipid composition resembling that of cell membranes, i.e., composed of different molar ratios of an unsaturated glycerophospholipid, sphingomyelin, and cholesterol (Chol) along a liquid-disordered-liquid-ordered tie line was explored. The application of a fluorescence multiprobe and multiparameter approach, together with multiple fluorescence resonance energy transfer (FRET) pairs, in… CONTINUE READING

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