Ceramide channels and their role in mitochondria-mediated apoptosis.

  title={Ceramide channels and their role in mitochondria-mediated apoptosis.},
  author={Marco Colombini},
  journal={Biochimica et biophysica acta},
  volume={1797 6-7},
A key, decision-making step in apoptosis is the release of proteins from the mitochondrial intermembrane space. Ceramide can self-assemble in the mitochondrial outer membrane to form large stable channels capable of releasing said proteins. Ceramide levels measured in mitochondria early in apoptosis are sufficient to form ceramide channels in the outer membrane. The channels are in dynamic equilibrium with non-conducting forms of ceramide in the membrane. This equilibrium can be strongly… CONTINUE READING


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