Ceramide and reactive oxygen species generated by H2O2 induce caspase-3-independent degradation of Akt/protein kinase B.

@article{Martn2002CeramideAR,
  title={Ceramide and reactive oxygen species generated by H2O2 induce caspase-3-independent degradation of Akt/protein kinase B.},
  author={Daniel San Mart{\'i}n and Marta Salinas and Naoya Fujita and Takashi Tsuruo and Antonio Cuadrado},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 45},
  pages={42943-52}
}
This study was designed to elucidate the mechanisms leading to down-regulation of the Akt/protein kinase B (PKB) survival pathway during H2O2-induced cell death. H2O2 produced early activation of Akt/PKB and also DNA damage that was followed by stabilization of p53 levels, formation of reactive oxygen species (ROS), and generation of ceramide through activation of a glutathione-sensitive neutral sphingomyelinase. These events correlated with long term dephosphorylation and subsequent… CONTINUE READING
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