Ceramide and apoptosis: exploring the enigmatic connections between sphingolipid metabolism and programmed cell death.

@article{Mullen2012CeramideAA,
  title={Ceramide and apoptosis: exploring the enigmatic connections between sphingolipid metabolism and programmed cell death.},
  author={Thomas D Mullen and Lina M Obeid},
  journal={Anti-cancer agents in medicinal chemistry},
  year={2012},
  volume={12 4},
  pages={340-63}
}
Programmed cell death, or apoptosis, is a complex process whereby eukaryotic cells react to physiologic or pathophysiologic stimuli by undergoing genetically programmed suicide. Programmed cell death involves many well-characterized signaling pathways including permeabilization of the mitochondrial outer membrane and activation of caspases. Other pathways, such as pro-apoptotic lipid signaling, are less understood despite many years of study. The sphingolipid ceramide has received considerable… CONTINUE READING

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