Ceramide and adenosine 5'-monophosphate-activated protein kinase are two novel regulators of 11beta-hydroxysteroid dehydrogenase type 1 expression and activity in cultured preadipocytes.

Abstract

Increased activity of intracellular glucocorticoid reactivating enzyme, 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) in obese adipose tissue contributes to adipose dysfunction. As recent studies have highlighted a potential role of preadipocytes in adipose dysfunction, we tested the hypothesis that a variety of metabolic stress mediated by… (More)

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@article{Arai2007CeramideAA, title={Ceramide and adenosine 5'-monophosphate-activated protein kinase are two novel regulators of 11beta-hydroxysteroid dehydrogenase type 1 expression and activity in cultured preadipocytes.}, author={N. Arai and Hiroaki Masuzaki and T. Tanaka and Takayuki Ishii and Satoshi Yasue and N. Kobayashi and T. Tomita and M. Noguchi and Toshiro Kusakabe and Junji Fujikura and Katsuko Ebihara and M. Hirata and Kazutaka Hosoda and T. Hayashi and Hiromi Sawai and Yasuhiko Minokoshi and Kentaro Nakao}, journal={Endocrinology}, year={2007}, volume={148 11}, pages={5268-77} }