Ceramide and Sphingosine-1-Phosphate in Cell Death Pathways : Relevance to the Pathogenesis of Alzheimer's Disease.

@article{Chakrabarti2016CeramideAS,
  title={Ceramide and Sphingosine-1-Phosphate in Cell Death Pathways : Relevance to the Pathogenesis of Alzheimer's Disease.},
  author={Sankha Shubhra Chakrabarti and Aritri Bir and Jit Poddar and Maitrayee Sinha and Anirban Ganguly and Sasanka Chakrabarti},
  journal={Current Alzheimer research},
  year={2016},
  volume={13 11},
  pages={
          1232-1248
        }
}
The metabolic turnover of sphingolipids produces several signaling molecules that profoundly affect the proliferation, differentiation and death of cells. In particular, an enormous body of information is available that defines the varied role of ceramide and sphingosine-1-phosphate in cell death and survival. This review specifically examines the role of ceramide and sphingosine-1- phosphate in triggering neuronal death in Alzheimer's disease by analyzing the data from post-mortem studies and… CONTINUE READING

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