Ceramide and Insulin Resistance: How Should the Issue Be Approached?

  title={Ceramide and Insulin Resistance: How Should the Issue Be Approached?},
  author={J. Cristopher Gorski},
There is a growing amount of data indicating that ceramide is involved in the generation of insulin resistance (1–3). However, investigation into the biological function of ceramide is a complex issue. First, there are no ceramide receptors on the plasma membrane. Second, the membrane is impermeable for ceramides containing long-chain fatty acid residues and only such ceramides seem to exist in nature. There are 13 and 12 ceramides containing different long-chain fatty acid residues that have… CONTINUE READING


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