Ceramide activates heterotrimeric protein phosphatase 2A.

  title={Ceramide activates heterotrimeric protein phosphatase 2A.},
  author={Rick T Dobrowsky and Craig Kamibayashi and Marc C. Mumby and Yusuf A. Hannun},
  journal={The Journal of biological chemistry},
  volume={268 21},
Ceramide activates a cytosolic protein phosphatase present in rat T9 glioma cells and rat brain. Ceramide-activated protein phosphatase (CAPP) was found to share several properties with protein phosphatase 2A (PP2A) leading to the hypothesis that ceramide may directly activate PP2A. PP2A was isolated as a heterotrimer (AB'C, AB alpha C), heterodimer (AC), or free C subunit, and the effect of ceramide on the catalytic activity was assessed. C2-ceramide, 5-20 microM, activated heterotrimeric PP2A… CONTINUE READING
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