Ceramide activates heterotrimeric protein phosphatase 2A.

@article{Dobrowsky1993CeramideAH,
  title={Ceramide activates heterotrimeric protein phosphatase 2A.},
  author={Rick T Dobrowsky and Craig Kamibayashi and Marc C. Mumby and Yusuf A. Hannun},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 21},
  pages={15523-30}
}
Ceramide activates a cytosolic protein phosphatase present in rat T9 glioma cells and rat brain. Ceramide-activated protein phosphatase (CAPP) was found to share several properties with protein phosphatase 2A (PP2A) leading to the hypothesis that ceramide may directly activate PP2A. PP2A was isolated as a heterotrimer (AB'C, AB alpha C), heterodimer (AC), or free C subunit, and the effect of ceramide on the catalytic activity was assessed. C2-ceramide, 5-20 microM, activated heterotrimeric PP2A… CONTINUE READING
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References

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J. Eiol. Chem

  • J. Eiol. Chem
  • 1993

Cell

  • M Kronke
  • Cell
  • 1992

J. B~ol. Chem

  • J. B~ol. Chem
  • 1992

Science

  • K A Dressler, S Mathias, R N Kolesnick
  • Science
  • 1992

J . Biol. Chem

  • M.-Y Kim, C Linardic, L Obeid, Y Hannun
  • J . Biol. Chem
  • 1990

J. Biol

  • T Okazaki, A Blelawska, R M Bell, Y A Hannun
  • J. Biol
  • 1990

Adu. Lipid Res. Annu. Reu. Biochem

  • R T Dobrowsky, Y A Hannun
  • Adu. Lipid Res. Annu. Reu. Biochem
  • 1989

J . Biol. Chem. Science

  • T Okazaki, R M Bell, Y Hannun
  • J . Biol. Chem. Science
  • 1989

J. protern Res

  • S Shenolikar, A C Nairn, M C Phospho-Mumby, K L Russell, L J Garrard, D D Green
  • J. protern Res
  • 1987

Eur. J. Biochem

  • H Y Tung, S Alemany, P Cohen
  • Eur. J. Biochem
  • 1986

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