Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis

@article{Teichgrber2008CeramideAM,
  title={Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis},
  author={Volker Teichgr{\"a}ber and M. D. Ulrich and Nicole Endlich and Joachim Riethmueller and Barbara Wilker and Cheyla Conceiç{\~a}o De Oliveira–Munding and Anna M. van Heeckeren and Mark L. Barr and Gabriele von K{\"u}rthy and Kurt Werner Schmid and Michael Weller and Burkhard T{\"u}mmler and Florian Lang and Heike Grassm{\'e} and Gerd K. D{\"o}ring and Erich Gulbins},
  journal={Nature Medicine},
  year={2008},
  volume={14},
  pages={382-391}
}
Microbial lung infections are the major cause of morbidity and mortality in the hereditary metabolic disorder cystic fibrosis, yet the molecular mechanisms leading from the mutation of cystic fibrosis transmembrane conductance regulator (CFTR) to lung infection are still unclear. Here, we show that ceramide age-dependently accumulates in the respiratory… CONTINUE READING