Ceramide Synthases Expression and Role of Ceramide Synthase-2 in the Lung: Insight from Human Lung Cells and Mouse Models

@inproceedings{Petrache2013CeramideSE,
  title={Ceramide Synthases Expression and Role of Ceramide Synthase-2 in the Lung: Insight from Human Lung Cells and Mouse Models},
  author={Irina Petrache and Krzysztof Kamocki and Christophe Poirier and Yael Pewzner-Jung and Elad L. Laviad and Kelly S. Schweitzer and Mary Van Demark and Matthew Justice and Walter C. Hubbard and Anthony H Futerman},
  booktitle={PloS one},
  year={2013}
}
Increases in ceramide levels have been implicated in the pathogenesis of both acute or chronic lung injury models. However, the role of individual ceramide species, or of the enzymes that are responsible for their synthesis, in lung health and disease has not been clarified. We now show that C24- and C16-ceramides are the most abundant lung ceramide species, paralleled by high expression of their synthetic enzymes, ceramide synthase 2 (CerS2) and CerS5, respectively. Furthermore, the ceramide… CONTINUE READING

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