Ceramide Mediates Ox-LDL-Induced Human Vascular Smooth Muscle Cell Calcification via p38 Mitogen-Activated Protein Kinase Signaling

@inproceedings{Liao2013CeramideMO,
  title={Ceramide Mediates Ox-LDL-Induced Human Vascular Smooth Muscle Cell Calcification via p38 Mitogen-Activated Protein Kinase Signaling},
  author={Lizhen Liao and Qin Jie Zhou and Yan Song and Weikang Wu and Huimin Yu and Sheng Wang and Yanling Chen and Meihong Ye and Lihe Lu},
  booktitle={PloS one},
  year={2013}
}
Vascular calcification is associated with significant cardiovascular morbidity and mortality, and has been demonstrated as an actively regulated process resembling bone formation. Oxidized low density lipoprotein (Ox-LDL) has been identified as a regulatory factor involved in calcification of vascular smooth muscle cells (VSMCs). Additionally, over-expression of recombinant human neutral sphingomyelinase (N-SMase) has been shown to stimulate VSMC apoptosis, which plays an important role in the… CONTINUE READING