Ceramide Inhibits the Inwardly Rectifying Potassium Current in GH3 Lactotrophs.


The effects of ceramide on ion currents in rat pituitary GH(3) cells were investigated. Hyperpolarization-elicited K(+) currents present in GH(3) cells were studied to determine the effect of ceramide and other related compounds on the inwardly rectifying K(+) current (I(K(IR))). Ceramide (C(2)-ceramide) suppressed the amplitude of I(K(IR)) in a… (More)
DOI: 10.1210/endo.142.11.8508


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