Ceramide 1-phosphate induces macrophage chemoattractant protein-1 release: involvement in ceramide 1-phosphate-stimulated cell migration.

@article{Arana2013Ceramide1I,
  title={Ceramide 1-phosphate induces macrophage chemoattractant protein-1 release: involvement in ceramide 1-phosphate-stimulated cell migration.},
  author={Lide Arana and Marta Ordo{\~n}ez and Alberto Ouro and I. L. Ortega Rivera and Patricia Gangoiti and Miguel Trueba and Antonio Gomez-Mu{\~n}oz},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2013},
  volume={304 11},
  pages={
          E1213-26
        }
}
The bioactive sphingolipid ceramide 1-phosphate (C1P) is implicated in inflammatory responses and was recently shown to promote cell migration. However, the mechanisms involved in these actions are poorly described. Using J774A.1 macrophages, we have now discovered a new biological activity of C1P: stimulation of monocyte chemoattractant protein-1 (MCP-1) release. This novel effect of C1P was pertussis toxin (PTX) sensitive, suggesting the intervention of Gi protein-coupled receptors. Treatment… CONTINUE READING

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