Ceramide-1-phosphate in cell survival and inflammatory signaling.

  title={Ceramide-1-phosphate in cell survival and inflammatory signaling.},
  author={Antonio Gomez-Mu{\~n}oz and Patricia Gangoiti and Maria H. Granado and L Taberna Arana and Alberto Ouro},
  journal={Advances in experimental medicine and biology},
An important metabolite of ceramide is ceramide-1-phosphate (C1P). This lipid second messenger was first demonstrated to be mitogenic for fibroblasts and macrophages and later shown to have antiapoptotic properties. C1P is also an important mediator of the inflammatory response, by stimulating the release of arachidonic acid through activation of group IVA cytosolic phospholipase A2, the initial rate-limiting step of eicosanoid biosynthesis. C1P is formed from ceramide by the action of a… CONTINUE READING
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