Ceramide‐1‐phosphate promotes cell survival through activation of the phosphatidylinositol 3‐kinase/protein kinase B pathway

@article{GomezMuoz2005Ceramide1phosphatePC,
  title={Ceramide‐1‐phosphate promotes cell survival through activation of the phosphatidylinositol 3‐kinase/protein kinase B pathway},
  author={Antonio Gomez-Mu{\~n}oz and Jennifer Y. Kong and Kuljit S Parhar and Shih-Wei Wang and Patricia Gangoiti and M{\'o}nica Gonz{\'a}lez and Sharlene Eivemark and Bill Salh and Vincent Duronio and Urs P. Steinbrecher},
  journal={FEBS Letters},
  year={2005},
  volume={579}
}
In this report, we show for the first time that ceramide‐1‐phosphate (C1P) stimulates the phosphatidylinositol 3‐kinase (PI3‐K)/protein kinase B (PKB) pathway, which is a major mechanism whereby growth factors promote cell survival. Also, C1P induced IκB phosphorylation, and enhanced the DNA binding activity of the transcription factor NF‐κB. Apoptotic macrophages showed a marked reduction of Bcl‐XL levels, and this was prevented by C1P. These findings suggest that C1P blocks apoptosis, at… 
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Activation of mTOR and RhoA is a major mechanism by which Ceramide 1-phosphate stimulates macrophage proliferation.
TLDR
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Implication of matrix metalloproteinases 2 and 9 in ceramide 1-phosphate-stimulated macrophage migration.
TLDR
The latter findings support the notion that C1P-stimulated macrophage migration is a receptor mediated effect, and point to MMP-2 and -9 as possible therapeutic targets to control inflammation.
Ceramide-1-phosphate in cell survival and inflammatory signaling.
TLDR
C1P has a dual regulatory capacity acting as an intracellular second messenger to regulate cell survival, or as extracellular receptor ligand to stimulate chemotaxis.
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