Ceramide: a potential mediator of apoptosis in human retinal pigment epithelial cells.

@article{Barak2001CeramideAP,
  title={Ceramide: a potential mediator of apoptosis in human retinal pigment epithelial cells.},
  author={Anıl Barak and Lawrence S. Morse and Tzipora Goldkorn},
  journal={Investigative ophthalmology & visual science},
  year={2001},
  volume={42 1},
  pages={247-54}
}
PURPOSE To investigate the signal transduction mechanisms involved in the cell death of human retinal pigment epithelial (RPE) cells after their exposure to either hydrogen peroxide (H(2)O(2)) or tri-butyl hydroxperoxide (tBH). METHODS Cultured human RPE (hRPE) cells were treated with the chemical oxidants tBH and H(2)O(2) as well as with the synthetic ceramide analogs C(2), C(6), and dihydroceramide for different time periods. Apoptosis was determined by TUNEL staining and annexin-V labeling… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 49 references

Similar Papers

Loading similar papers…