Ceramidases, roles in sphingolipid metabolism and in health and disease.

  title={Ceramidases, roles in sphingolipid metabolism and in health and disease.},
  author={Nicolas Coant and Wataru Sakamoto and Cungui Mao and Yusuf A. Hannun},
  journal={Advances in biological regulation},
Over the past three decades, extensive research has been able to determine the biologic functions for the main bioactive sphingolipids, namely ceramide, sphingosine, and sphingosine 1-phosphate (S1P) (Hannun, 1996; Hannun et al., 1986; Okazaki et al., 1989). These studies have managed to define the metabolism, regulation, and function of these bioactive sphingolipids. This emerging body of literature has also implicated bioactive sphingolipids, particularly S1P and ceramide, as key regulators… CONTINUE READING


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