Cephem antibiotics and alcohol metabolism.

  title={Cephem antibiotics and alcohol metabolism.},
  author={M Yanagihara and K. Okada and Masakatsu Nozaki and Kaito Tsurumi and Hajime Fujimura},
  journal={The Japanese journal of antibiotics},
  volume={38 3},
Mechanisms of the disulfiram-like reaction of cephem antibiotics were studied. Changes in ethanol (EtOH) and acetaldehyde (AcH) levels in the blood with EtOH loading following daily intravenous administration of cephem antibiotics were determined in rats and the following were found: The daily intravenous injection of cefazolin, cefotiam (CTM), cefsulodin, cefoxitin or ceftizoxime in no way varied the changes in the EtOH and AcH levels in the blood with EtOH loading. The daily intravenous… Expand
Pharmacokinetics of latamoxef and N-methyltetrazolethiol in rats associated with the development of disulfiram-like effects.
The results indicate that the development of disulfiram-like effects of N-methyltetrazolethiol-containing antibiotics is closely related to the pharmacokinetic profile of NMTT released from its parent drugs. Expand
Effects of beta-lactam antibiotics and N-methyltetrazolethiol on the alcohol-metabolizing system in rats.
The results suggest that the disulfiram-like effect of beta-lactam antibiotics is mediated by N-methyltetrazolethiol released from them. Expand
A comparative study on the effects of disulfiram and beta-lactam antibiotics on the acetaldehyde-metabolizing system in rats.
Several beta-lactam antibiotics, especially those containing N-methyltetrazolethiol groups at the 3-position of the cephalosporin nucleus, affect the alcohol-metabolizing system in rats and are compared with disulfiram, well-known as a potent inhibitor of aldehyde dehydrogenase (ALDH). Expand
Effects of beta-lactam antibiotics on the acetaldehyde-metabolizing system in germ-free rats.
The results indicate that intestinal bacteria do no participate in the development of the disulfiram-like reaction of several beta-lactam antibiotics. Expand
GC-MS based metabolomics of CSF and blood serum: Metabolic phenotype for a rat model of cefoperazone-induced disulfiram-like reaction.
Concomitant ingestion of alcohol and cefoperazone generated disulfiram-like reaction by way of disrupting normal metabolic pathway, thereby affects energy metabolism and neural transmission. Expand
Cephalosporin induced disulfiram-like reaction: a retrospective review of 78 cases.
It is important for clinicians to educate patients that no alcohol should be used if one is taking cephalosporin, and clinicians should keep in mind that cep Halospor in should not be prescribed for any alcoholics. Expand
Antimicrobial drug-nutrition interactions: Consistency of information for generic drugs
One third of generic antimicrobial products had inconsistent drug-nutrition interaction statements, and given the potential clinical implications, strategies for further harmonization of this information should be considered. Expand


Disulfiram as a tool in the studies on the metabolism of acetaldehyde in rats.
It is suggested that the mitochondrial low-Km enzyme has a primary role in the regulation of the hepatic output of acetaldehyde, and the results will be discussed with special reference to the site and kinetics ofacetaldehyde oxidation during ethanol metabolism in rat liver. Expand
Effects of Tetraethylthiuramdisulfide (Antabuse) on the Metabolism and Consumption of Ethanol in Mice
&NA; Acetaldehyde accumulation following ethanol administration and the effects of Antabuse on ethanol metabolism were studied in C57BL/CrgI and DBA/2Crgl mice. In alcohol preference tests,Expand
Disulfiram-like reaction to a cephalosporin.
A peculiar facial flushing and tachycardia occurring two to three days after discharge and within a few minutes after drinking one or two glasses of beer is noted. Expand
Disulfiram-like reaction associated with a parenteral cephalosporin.
Cefoperazone (T-1551), a semisynthetic, parenteral cephalosporin undergoing clinical trials in the United States, was administered in single 1, 2, and 3-g doses to 12 healthy volunteers. Expand
Metabolic fate of SCE-1365, a new broad-spectrum cephalosporin, after parenteral administration to rats and dogs
An active transport process appeared to be involved in biliary excretion in rats, and a large amount of the dosed 14C was excreted in urine as unaltered antibiotic. Expand
Mechanism of the inhibition of aldehyde dehydrogenase in vivo by disulfiram and diethyldithiocarbamate.
Results indicate that disulfiram is an irreversible inhibitor of aldehyde dehydrogenase in vivo and can be blocked by cycloheximide. Expand
The determination of acetaldehyde in biological samples by head-space gas chromatography.
The method described measures the total AcH content without regard to any binding in biological samples by head-space gas chromatography, and some of the AcH in rat blood was shown to be bound. Expand
Reevaluation of the disulfiram-alcohol reaction in man.
The intensity of the disulfiram-alcohol reaction is found to depend on the blood acetaldehyde level, a disulfiram-induced predisposition reflected by alkalosis, and an individual predispositionExpand
Absorption, distribution, metabolism and excretion of cefotetan (YM 09330), a new broad spectrum cephamycin, in experimental animals
  • Chemotherapy 30 (Suppl. 1): S106•`S118,
  • 1982
Side effects of YM 09330
  • Chemotherapy 29:
  • 1981