Cephem antibiotics and alcohol metabolism.

@article{Yanagihara1985CephemAA,
  title={Cephem antibiotics and alcohol metabolism.},
  author={M Yanagihara and K. Okada and Masakatsu Nozaki and Kaito Tsurumi and Hajime Fujimura},
  journal={The Japanese journal of antibiotics},
  year={1985},
  volume={38 3},
  pages={
          634-42
        }
}
Mechanisms of the disulfiram-like reaction of cephem antibiotics were studied. Changes in ethanol (EtOH) and acetaldehyde (AcH) levels in the blood with EtOH loading following daily intravenous administration of cephem antibiotics were determined in rats and the following were found: The daily intravenous injection of cefazolin, cefotiam (CTM), cefsulodin, cefoxitin or ceftizoxime in no way varied the changes in the EtOH and AcH levels in the blood with EtOH loading. The daily intravenous… Expand
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