Cepharanthine exerts antitumor activity on cholangiocarcinoma by inhibiting NF-kappaB.

@article{Seubwai2010CepharanthineEA,
  title={Cepharanthine exerts antitumor activity on cholangiocarcinoma by inhibiting NF-kappaB.},
  author={Wunchana Seubwai and Kulthida Vaeteewoottacharn and Masateru Hiyoshi and Shinya Suzu and Anucha Puapairoj and Chairisi Wongkham and Seiji Okada and Sopit Wongkham},
  journal={Cancer science},
  year={2010},
  volume={101 7},
  pages={1590-5}
}
Cholangiocarcinoma (CCA) is a major cause of cancer deaths in northeast Thailand. It is aggressive, highly metastatic, and responds poorly to traditional chemotherapy. We demonstrated the potential for Cepharanthine (CEP), a biscoclaurine alkaloid extracted from Stephania cepharantha, to treat CCA. CEP significantly inhibited growth of human CCA cell lines in a dose- and time-dependent manner, regardless of the histologic type of tumor origin. Increasing cell apoptosis via caspase-3 and capase… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

Similar Papers

Loading similar papers…