Cepharanthine exerts antitumor activity on cholangiocarcinoma by inhibiting NF-kappaB.

  title={Cepharanthine exerts antitumor activity on cholangiocarcinoma by inhibiting NF-kappaB.},
  author={Wunchana Seubwai and Kulthida Vaeteewoottacharn and Masateru Hiyoshi and Shinya Suzu and Anucha Puapairoj and Chairisi Wongkham and Seiji Okada and Sopit Wongkham},
  journal={Cancer science},
  volume={101 7},
Cholangiocarcinoma (CCA) is a major cause of cancer deaths in northeast Thailand. It is aggressive, highly metastatic, and responds poorly to traditional chemotherapy. We demonstrated the potential for Cepharanthine (CEP), a biscoclaurine alkaloid extracted from Stephania cepharantha, to treat CCA. CEP significantly inhibited growth of human CCA cell lines in a dose- and time-dependent manner, regardless of the histologic type of tumor origin. Increasing cell apoptosis via caspase-3 and capase… CONTINUE READING


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