Cephalosporolide B serving as a versatile synthetic precursor: asymmetric biomimetic total syntheses of cephalosporolides C, E, F, G, and (4-OMe-)G.

@article{Song2013CephalosporolideBS,
  title={Cephalosporolide B serving as a versatile synthetic precursor: asymmetric biomimetic total syntheses of cephalosporolides C, E, F, G, and (4-OMe-)G.},
  author={L. Song and Y. Liu and Rongbiao Tong},
  journal={Organic letters},
  year={2013},
  volume={15 22},
  pages={
          5850-3
        }
}
  • L. Song, Y. Liu, Rongbiao Tong
  • Published 2013
  • Chemistry, Medicine
  • Organic letters
  • Cephalosporolide B (Ces-B) was efficiently synthesized and exploited for the first time as a versatile biomimetic synthetic precursor for the chemical syntheses of not only cephalosporolides C, G, and (4-OMe-) G via a challenging diastereoselective oxa-Michael addition but also the structurally unprecedented cephalosporolides E and F via a novel biomimetic ring-contraction rearrangement. These findings provide the first direct chemical evidence that Ces-B may be the true biosynthetic precursor… CONTINUE READING
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